Reconstitution & Administration
Reconstituting KCENTRA using the Mix2Vial® Transfer Set
Watch a step-by-step reconstitution video
How to administer KCENTRA
- Do not mix KCENTRA with other medicinal products; administer through a separate infusion line
- Visually inspect the reconstituted solution for particulate matter and discoloration prior to administration whenever solution and container permit. Reconstituted KCENTRA solution should be colorless, clear to slightly opalescent, and free from visible particles. Do not use if the solution is cloudy, discolored, or contains particulates
- Use aseptic technique when administering KCENTRA
- Administer at room temperature
- Administer by intravenous infusion at a rate of 0.12 mL/kg/min (~3 units/kg/min), up to a maximum rate of 8.4 mL/min (~210 units/min)
- Administer concurrently with vitamin K
- No blood should enter the syringe, as there is a possibility of fibrin clot formation
Storing KCENTRA after reconstitution
- KCENTRA must be used within 4 hours following reconstitution. Reconstituted product can be stored at 2–25°C. If cooled, the solution should be warmed to 20–25°C prior to administration
- Do not freeze the reconstituted product. Discard partially used vials
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