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References

  1. Data on File. Available from CSL Behring as DOF KCT-010.
  2. Go AS, Leong TK, Sung SH, et al. Thromboembolism after treatment with 4 factor prothrombin complex concentrate or plasma for warfarin related bleeding. J Thromb Thrombolysis. 2022;54:470-479.
  3. Sarode R, Milling T, Refaai M, et al. Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circulation. 2013;128(11):1234-1243.
  4. Goldstein J, Refaai M, Milling T, et al. Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomized trial. Lancet. 2015;385:2077-2087.
  5. Abraham NS, Barkun AN, Sauer BG, et al. American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period. Am J Gastroenterol. 2022;117(4):542-558.
  6. Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2022;53:e282-e361.
  7. Tomaselli G, Mahaffey K, Cuker A, et al. 2020 ACC expert consensus decision pathway on management of bleeding in patients on oral anticoagulants. J Am Col Card. 2020;76(5):595-622.
  8. Baugh C, Levine M, Cornutt D, et al. Anticoagulant reversal strategies in the emergency department setting: recommendations of a multidisciplinary expert panel. Ann Emerg Med. 2020;76(4):470-485.
  9. Hornor MA, Duane TM, Ehlers AP, et al. American College of Surgeons’ Guidelines for the perioperative management of antithrombotic medication. J Am Coll Surg. 2018;227(5):521-536.e1.
  10. Witt D, Nieuwlaat R, Clark N, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy. Blood Adv. 2018;2(22):3257-3291.
  11. Frontera J, Lewin J, Rabinstein A, et al. Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the Neurocritical Society and Society of Critical Care Medicine. Neurocrit Care. 2016;24(1):6-46.
  12. AABB. Circular of information for the use of human blood and blood components. AABB. 2017;1-78.
  13. Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e152S-e184S.
  14. Hood C, Goldstein JN, Milling TJ, et al. INR and vitamin K-dependent factor levels after vitamin K antagonist reversal with 4F-PCC or plasma. Blood Adv. 2023;7(10):2206-2213.
  15. Schulman S, Bijsterveld N. Anticoagulants and their reversal. Transfus Med Rev. 2007;21(1):37-48.
  16. Data on File. Available from CSL Behring as DOF KCT-011.
  17. Refaai MA, Goldstein JN, Lee ML, et al. Increased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversal. Transfusion. 2015;55:2722-2729.
  18. US Department of Health and Human Services, Centers for Medicare & Medicaid Services. Medicare program; hospital inpatient prospective payment systems for acute care hospitals and the long-term care hospital prospective payment system and policy changes and fiscal year 2024 rates; quality programs and medicare promoting interoperability program requirements for eligible hospitals and critical access hospitals; rural emergency hospital and physician-owned hospital requirements; and provider and supplier disclosure of ownership; and medicare disproportionate share hospital (DSH) payments: counting certain days associated with section 1115 demonstrations in the medicaid fraction. https://www.govinfo.gov/content/pkg/FR-2024-02-21/pdf/FR-2024-02-21.pdf. Accessed February 21, 2024.
  19. US Department of Health and Human Services, Centers for Medicare & Medicaid Services. July 2021 HCPCS Release & Code Sets. https://www.cms.gov/Medicare/Coding/HCPCSReleaseCodeSets/HCPCS-Quarterly-Update. Accessed February 21, 2024.
  20. Ageno W, Gallus AS, Wittkowsky A, et al. Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141(suppl 2):e44S-e88S.
  21. Holt T, Taylor S, Abraham P, et al. Three-versus four-factor prothrombin complex concentrate for the reversal of warfarin-induced bleeding. Int J Crit Illn Inj Sci. 2018;8(1):36-40.